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Ilya Ruvinsky
Bioinformatics Seminar - U of C Department of Ecology and Eolution
Computational and comparative view of evolution and development in
April 25, 2006 2:00pm
Abstract:
The availability of complete genome sequences of a wide variety of
organisms, an essential part of the “genomics revolution”, has greatly
accelerated discovery in biology over the last decade. This abundance
of data has brought to the forefront comparative and computational
methods. I will describe two projects that take advantage of these approaches.
The first uses comparative analyses to elucidate the patterns and
functional consequences of changes in regulatory elements that control
spatial and temporal patterns of gene expression. If successful, it
will improve our ability to predict functional elements from sequence data alone.
The second project exploits our ability to use computation to predict
gene expression patterns. We have identified a number of genes whose
products are present in all neurons and few, if any, other cell types.
Together these genes constitute a “genetic definition” of neurons as a
cell type. Since many of these genes are also highly conserved between
all animals studied to date, we can use them to infer, for the first
time, the origin and diversification of neurons in animal evolution.
Please visit http://pondside.uchicago.edu/ecol-evol/faculty/ruvinsky_i.html for more information about these projects.
If you have questions, or would like to meet the speaker, please contact Ponda at 4-1994 or pondabarnes@tti-c.org. For information on future TTI-C talks or events, please go to the TTI-C Events page.