Aly Azeem Khan

Research Assistant Professor
Toyota Technological Institute at Chicago
  1. Cho S, Wu C, Yasuda T, Cruz L, Khan AA, Lin LL, Nguyen DT, Miller M, Lee H, Kuo M, Broide DH, Rajewsky K, Rudensky AY, and Lu LF. miR-23~27~24 clusters control effector T cell differentiation and function. Journal of Experimental Medicine. 2016 Feb; In Press.

  2. Canani RB, Sangwan N, Stefka AT, Nocerino R, Paparo L, Aitoro R, Calignano A, Khan AA, Gilbert JA, and Nagler CR. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants. The ISME Journal. 2015 Sep 22.

  3. Lee HM, Fleige A, Forman R, Cho S, Khan AA, Lin LL, Nguyen DT, O'Hara-Hall A, Yin Z, Hunter CA, Muller W, Lu LF. IFNγ signaling endows DCs with the capacity to control type I inflammation during parasitic infection through promoting T-bet+ regulatory T cells. PLoS Pathogens. 2015 Feb 6;11(2):e1004635.

  4. Varanasi V, Khan AA, and Chervonsky AV. Loss of the death receptor CD95 (Fas) expression by dendritic cells protects from a chronic viral infection. Proc Natl Acad Sci (PNAS). 2014 Jun 10;111(23):8559-64.

  5. Singh H, Khan AA, and Dinner AR. Gene regulatory networks in the immune system. Trends in Immunology. 2014 May;35(5):211-218.

  6. Lugt BV, Khan AA, Hackney J, Agrawal S, Lesch J, Zhou M, Lee WP, Park H, Xu M, DeVoss J, Spooner CJ, Chalouni C, Delamarre L, Mellman I, and Singh H. Transcriptional programming of dendritic cells for enhanced MHCII antigen presentation. Nature Immunology. 2014 Feb;15(2):161-7.

  7. Spooner CJ, Lesch J, Yan D, Khan AA, Abbas A, Ramirez-Carrozzi V, Zhou M, Soriano R, Eastham-Anderson J, Diehl L, Lee WP, Modrusan Z, Pappu R, Xu M, Devoss J, and Singh H. Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1. Nature Immunology. 2013 Dec;14(12):1229-36.

  8. Yurkovetskiy L*, Burrows M*, Khan AA*, Graham L, Volchkov P, Becker L, Antonopoulos D, Umesaki Y, and Chervonsky AV. (* Equal contribution) Gender bias in autoimmunity is influenced by microbiota. Immunity. 2013 Aug 22;39(2):400-12.

  9. Loeb GB*, Khan AA*, Canner D, Hiatt JB, Shendure J, Darnell RB, Leslie CS, and Rudensky AY. (* Equal contribution) Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Molecular Cell. 2012 Dec 14;48(5):760-70.

  10. Glasmacher E, Agrawal S, Chang A, Murphy T, Zeng W, Lugt BV, Khan AA, Ciofani M, Spooner C, Rutz S, Hackney J, Nurieva R, Escalante CR, Ouyang W, Littman D, Murphy KM, and Singh H. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science. 2012 Nov 16;338(6109):975-80.

  11. Setty M, Helmy K, Khan AA, Silber J, Arvey A, Neezen F, Agius P, Huse JT, Holland EC, and Leslie CS. Inferring transcriptional and microRNA-mediated regulatory programs in glioblastoma. Nature-EMBO Molecular Systems Biology. 2012 Aug 28;8:605.

  12. Pastar I, Khan AA, Stojadinovic O, Lebrun EA, Medina MC, Brem H, Kirsner RS, Jimenez JJ, Leslie C, and Tomic-Canic M. Induction of Specific MicroRNAs Inhibits Cutaneous Wound Healing. Journal of Biological Chemistry. 2012 Aug 24;287(35):29324-35.

  13. Buehler E, Khan AA, Marine S, Rajaram M, Bahl A, Burchard J, and Ferrer M. siRNA off-target effects in genome-wide screens identify signaling pathway members. Scientific Reports. 2012;2:428.

  14. Mavrakis KJ, Van Der Meulen J, Wolfe AL, Liu X, Mets E, Taghon T, Khan AA, Setty M, Rondou P, Vandenberghe P, Delabesse E, Benoit Y, Socci NB, Leslie CS, Van Vlierberghe P, Speleman F, and Wendel HG. A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL). Nature Genetics. 2011 Jun;43(7):673-8.

  15. Mavrakis KJ, Wolfe AL, Oricchio E, Palomero T, Keersmaecker K, McJunkin K, Zuber J, James T, Khan AA, Leslie CS, Parker JS, Paddison PJ, Tam W, Ferrando A, and Wendel HG. Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia. Nature Cell Biology. 2010 Apr;12(4):372-9.

  16. Khan AA, Betel D, Miller ML, Sander C, Leslie CS, and Marks DS. Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nature Biotechnology. 2009 Jun;27(6):549-55.

  17. Potluri S, Khan AA, Kuzminykh A, Bujnicki JM, Friedman AM, and Bailey-Kellogg C. Geometric analysis of cross-linkability for protein fold discrimination. Pacific Symposium on Biocomputing. 2004;447-458.


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